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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497070
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
10000±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497070
Synonyms:
US11001561, Compound 60 | US11702392, Compound 60
Type:
Small organic molecule
Emp. Form.:
C23H28Cl2N4O
Mol. Mass.:
447.401
SMILES:
Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CC2CC3CC(C3(C)C)C2(CN)C1 |(-5.37,2.16,;-4.79,.73,;-3.26,.52,;-2.69,-.91,;-3.63,-2.12,;-5.16,-1.91,;-6.1,-3.13,;-5.74,-.48,;-7.26,-.27,;-7.84,1.16,;-9.37,1.37,;-10.31,.15,;-9.73,-1.27,;-10.68,-2.49,;-8.21,-1.49,;-7.63,-2.91,;-1.16,-1.12,;-.44,-2.48,;1.08,-2.21,;2.3,-3.16,;3.72,-2.58,;2.91,-1.47,;2.72,-.11,;3.93,-1.05,;4.92,.13,;5.47,-1.21,;1.29,-.69,;1.34,.85,;.04,1.67,;-.09,-.01,)|
Structure:
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