Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497115
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
3900±n/a nM
Citation
 Jorand-Lebrun, CBoivin, RJohnson, TWang, YXiao, YChen, XLinde, NMusch, DKumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497115
Synonyms:
US11001561, Compound 90 | US11702392, Compound 90
Type:
Small organic molecule
Emp. Form.:
C20H24Cl2N4O
Mol. Mass.:
407.337
SMILES:
Cc1nc(N2CCCC3(CCC3N)C2)c(C)c(=O)n1-c1cccc(Cl)c1Cl |(8.79,4.77,;7.25,4.77,;6.48,3.44,;4.94,3.44,;4.17,2.1,;4.94,.77,;4.17,-.56,;2.63,-.56,;1.86,.77,;.77,1.86,;-.32,.77,;.77,-.32,;.77,-1.86,;2.63,2.1,;4.17,4.77,;2.63,4.77,;4.94,6.1,;4.17,7.44,;6.48,6.1,;7.25,7.44,;8.79,7.44,;9.56,8.77,;8.79,10.11,;7.25,10.11,;6.48,11.44,;6.48,8.77,;4.94,8.77,)|
Structure:
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