Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497122
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
78.0±n/a nM
Citation
 Jorand-Lebrun, CBoivin, RJohnson, TWang, YXiao, YChen, XLinde, NMusch, DKumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497122
Synonyms:
US11001561, Compound 97 | US11702392, Compound 97
Type:
Small organic molecule
Emp. Form.:
C21H26BrClN4O2
Mol. Mass.:
481.814
SMILES:
C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Br)c(=O)c2C)[C@@H]1N |wD:27.31,1.0,(-1.25,-.91,;;,1.54,;1.46,2.02,;2.37,.77,;3.14,2.1,;4.68,2.1,;5.45,.77,;4.68,-.56,;3.14,-.56,;6.99,.77,;7.76,-.56,;9.3,-.56,;10.07,-1.9,;10.07,.77,;11.61,.77,;12.38,-.56,;13.92,-.56,;14.69,.77,;13.92,2.1,;14.69,3.44,;12.38,2.1,;11.61,3.44,;9.3,2.1,;10.07,3.44,;7.76,2.1,;6.99,3.44,;1.46,-.48,;1.94,-1.94,)|
Structure:
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