Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497231
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
275±n/a nM
Citation
 Wang, XZheng, HZhao, JZhang, WFrye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497231
Synonyms:
(1S,4R)-4-(5-(1-((2- methoxyethyl)sulfonyl) piperidin-4-yl)-2-(((S)-pentan- 2-yl)amino)-7H- pyrrolo[2,3-d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 4
Type:
Small organic molecule
Emp. Form.:
C25H41N5O4S
Mol. Mass.:
507.689
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(=O)(=O)CCOC |r,wU:13.12,wD:3.3,16.16,(-8.93,-2.31,;-7.59,-1.54,;-6.26,-2.31,;-4.93,-1.54,;-4.93,,;-3.59,-2.31,;-2.26,-1.54,;-2.26,,;-.93,.77,;.41,,;1.87,.48,;2.78,-.77,;1.87,-2.02,;2.35,-3.48,;3.85,-3.8,;4.33,-5.27,;3.3,-6.41,;3.78,-7.87,;1.79,-6.09,;1.32,-4.63,;.41,-1.54,;-.93,-2.31,;2.35,1.94,;3.85,2.26,;4.33,3.73,;3.3,4.87,;1.79,4.55,;1.32,3.09,;3.78,6.33,;3.78,7.87,;2.29,6.73,;5.26,5.94,;5.66,4.45,;7.15,4.05,;8.24,5.14,)|
Structure:
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