Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497239
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<50±n/a nM
Citation
 Wang, XZheng, HZhao, JZhang, WFrye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497239
Synonyms:
(1R,4R)-4-(5-((1R,3S,5S)- 8-azabicyclo[3.2.1]octan-3- yl)-2-(butylamino)-7H- pyrrolo[2,3-d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 12
Type:
Small organic molecule
Emp. Form.:
C23H35N5O
Mol. Mass.:
397.5569
SMILES:
CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CC2CCC(C1)N2 |r,wU:12.11,wD:15.15,THB:9:21:28:24.25,(-7.44,-.93,;-6.11,-.16,;-4.78,-.93,;-3.44,-.16,;-2.11,-.93,;-.78,-.16,;-.78,1.38,;.56,2.15,;1.89,1.38,;3.36,1.86,;4.26,.61,;3.36,-.63,;3.83,-2.1,;5.34,-2.42,;5.81,-3.88,;4.78,-5.03,;5.26,-6.49,;3.28,-4.71,;2.8,-3.24,;1.89,-.16,;.56,-.93,;3.83,3.32,;5.18,4.07,;5.96,5.4,;4.87,6.49,;5.01,5.34,;6.1,4.26,;5.32,2.93,;7.44,5,)|
Structure:
Search PDB for entries with ligand similarity: