Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497268
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, XZheng, HZhao, JZhang, WFrye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497268
Synonyms:
(4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(2-methylpyridin-4- yl)methanone | US11001586, Example 35
Type:
Small organic molecule
Emp. Form.:
C29H40N6O2
Mol. Mass.:
504.6669
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccnc(C)c1 |r,wU:13.12,wD:3.3,16.16,(-8.58,-2.22,;-7.25,-1.45,;-5.92,-2.22,;-4.58,-1.45,;-4.58,.09,;-3.25,-2.22,;-1.91,-1.45,;-1.91,.09,;-.58,.86,;.75,.09,;2.22,.57,;3.12,-.68,;2.22,-1.92,;2.69,-3.39,;4.2,-3.71,;4.68,-5.17,;3.64,-6.32,;4.12,-7.78,;2.14,-6,;1.66,-4.53,;.75,-1.45,;-.58,-2.22,;2.69,2.03,;4.2,2.35,;4.68,3.82,;3.64,4.96,;2.14,4.64,;1.66,3.18,;4.12,6.43,;3.39,7.78,;5.61,6.03,;6.7,7.12,;8.18,6.72,;8.58,5.23,;7.49,4.14,;7.89,2.66,;6.01,4.54,)|
Structure:
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