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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497271
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
275±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497271
Synonyms:
(4-(2-(((1R,2R)-2- ethylcyclopropyl)amino)-7- ((1R,4R)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1-yl)(pyridin- 4-yl)methanone | US11001586, Example 43
Type:
Small organic molecule
Emp. Form.:
C28H36N6O2
Mol. Mass.:
488.6244
SMILES:
CC[C@@H]1C[C@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccncc1 |r,wU:4.5,13.13,wD:16.17,2.1,(-8.02,-3.76,;-8.02,-2.22,;-6.69,-1.45,;-5.92,-.11,;-5.15,-1.45,;-3.81,-2.22,;-2.48,-1.45,;-2.48,.09,;-1.14,.86,;.19,.09,;1.65,.57,;2.56,-.68,;1.65,-1.92,;2.13,-3.39,;3.64,-3.71,;4.11,-5.17,;3.08,-6.32,;3.56,-7.78,;1.57,-6,;1.1,-4.53,;.19,-1.45,;-1.14,-2.22,;2.13,2.03,;3.64,2.35,;4.11,3.82,;3.08,4.96,;1.57,4.64,;1.1,3.18,;3.56,6.43,;2.82,7.78,;5.04,6.03,;5.44,4.54,;6.93,4.14,;8.02,5.23,;7.62,6.72,;6.13,7.12,)|
Structure:
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