Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497273
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497273
Synonyms:
(1S,4R)-4-(5-(1'-methyl- [1,4'-bipiperidin]-4-yl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 52
Type:
Small organic molecule
Emp. Form.:
C28H46N6O
Mol. Mass.:
482.7044
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C1CCN(C)CC1 |r,wU:13.12,wD:16.16,3.3,(-7.34,-3.74,;-6.01,-2.97,;-4.68,-3.74,;-3.34,-2.97,;-3.34,-1.43,;-2.01,-3.74,;-.67,-2.97,;-.67,-1.43,;.66,-.66,;1.99,-1.43,;3.46,-.95,;4.36,-2.2,;3.46,-3.44,;3.93,-4.91,;5.44,-5.23,;5.92,-6.69,;4.88,-7.84,;5.36,-9.3,;3.38,-7.52,;2.9,-6.05,;1.99,-2.97,;.66,-3.74,;3.93,.51,;5.44,.83,;5.92,2.3,;4.88,3.44,;3.38,3.12,;2.9,1.66,;5.36,4.91,;6.87,5.23,;7.34,6.69,;6.31,7.84,;6.79,9.3,;4.81,7.52,;4.33,6.05,)|
Structure:
Search PDB for entries with ligand similarity: