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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497274
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497274
Synonyms:
(1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (piperidin-4- ylmethyl)piperidin-4-yl)- 7H-pyrrolo[2,3- d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 53
Type:
Small organic molecule
Emp. Form.:
C28H46N6O
Mol. Mass.:
482.7044
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCNCC2)CC1 |r,wU:13.12,wD:16.16,3.3,(-8.61,-2.59,;-7.28,-1.82,;-5.94,-2.59,;-4.61,-1.82,;-4.61,-.28,;-3.28,-2.59,;-1.94,-1.82,;-1.94,-.28,;-.61,.49,;.72,-.28,;2.19,.19,;3.09,-1.05,;2.19,-2.3,;2.66,-3.76,;4.17,-4.08,;4.65,-5.55,;3.62,-6.69,;4.09,-8.16,;2.11,-6.37,;1.63,-4.91,;.72,-1.82,;-.61,-2.59,;2.66,1.66,;4.17,1.98,;4.65,3.44,;3.62,4.59,;4.09,6.05,;5.6,6.37,;6.63,5.23,;8.14,5.55,;8.61,7.01,;7.58,8.16,;6.07,7.84,;2.11,4.27,;1.63,2.8,)|
Structure:
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