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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497276
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<3±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497276
Synonyms:
(2,6-dimethylpyridin-4- yl)(4-(2-(((1S,2S)-2- ethylcyclopropyl)amino)-7- ((1r,4S)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1- yl)methanone | US11001586, Example 55
Type:
Small organic molecule
Emp. Form.:
C30H40N6O2
Mol. Mass.:
516.6776
SMILES:
CC[C@H]1C[C@@H]1Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.13,2.1,wD:4.5,16.17,(-8.36,-3.77,;-8.36,-2.23,;-7.03,-1.46,;-6.26,-.13,;-5.49,-1.46,;-4.16,-2.23,;-2.82,-1.46,;-2.82,.08,;-1.49,.85,;-.16,.08,;1.31,.56,;2.21,-.69,;1.31,-1.94,;1.78,-3.4,;3.29,-3.72,;3.77,-5.19,;2.74,-6.33,;3.21,-7.79,;1.23,-6.01,;.75,-4.55,;-.16,-1.46,;-1.49,-2.23,;1.78,2.02,;3.29,2.34,;3.77,3.81,;2.74,4.95,;1.23,4.63,;.75,3.16,;3.21,6.41,;2.48,7.77,;4.7,6.02,;5.79,7.1,;7.28,6.71,;8.36,7.79,;7.67,5.22,;6.59,4.13,;6.98,2.64,;5.1,4.53,)|
Structure:
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