Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497281
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
275±n/a nM
Citation
 Wang, XZheng, HZhao, JZhang, WFrye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497281
Synonyms:
(4-(7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(1H-pyrrol-2- yl)methanone | US11001586, Example 60
Type:
Small organic molecule
Emp. Form.:
C27H38N6O2
Mol. Mass.:
478.6296
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1ccc[nH]1 |r,wU:13.12,wD:16.16,3.3,(-8.33,-2.22,;-7,-1.45,;-5.67,-2.22,;-4.33,-1.45,;-4.33,.09,;-3,-2.22,;-1.67,-1.45,;-1.67,.09,;-.33,.86,;1,.09,;2.47,.57,;3.37,-.68,;2.47,-1.92,;2.94,-3.39,;4.45,-3.71,;4.92,-5.17,;3.89,-6.32,;4.37,-7.78,;2.39,-6,;1.91,-4.53,;1,-1.45,;-.33,-2.22,;2.94,2.03,;4.45,2.35,;4.92,3.82,;3.89,4.96,;2.39,4.64,;1.91,3.18,;4.37,6.43,;3.63,7.78,;5.86,6.03,;7,7.06,;8.33,6.29,;8.01,4.78,;6.48,4.62,)|
Structure:
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