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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497290
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497290
Synonyms:
(2,6-dimethylpyridin-4- yl)(4-(2-((2- ethylbutyl)amino)-7- ((1r,4r)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1- yl)methanone | US11001586, Example 69
Type:
Small organic molecule
Emp. Form.:
C31H44N6O2
Mol. Mass.:
532.7201
SMILES:
CCC(CC)CNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:14.13,wD:17.17,(-8.89,-3.32,;-7.56,-2.55,;-6.22,-3.32,;-6.22,-4.86,;-7.56,-5.63,;-4.89,-2.55,;-3.55,-3.32,;-2.22,-2.55,;-2.22,-1.01,;-.89,-.24,;.45,-1.01,;1.91,-.54,;2.82,-1.78,;1.91,-3.03,;2.39,-4.5,;3.89,-4.82,;4.37,-6.28,;3.34,-7.42,;3.82,-8.89,;1.83,-7.1,;1.36,-5.64,;.45,-2.55,;-.89,-3.32,;2.39,.93,;3.89,1.25,;4.37,2.71,;3.34,3.86,;1.83,3.53,;1.36,2.07,;3.82,5.32,;2.78,6.46,;5.32,5.64,;5.8,7.1,;7.3,7.42,;7.78,8.89,;8.33,6.28,;7.86,4.82,;8.89,3.67,;6.35,4.5,)|
Structure:
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