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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497294
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
275±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497294
Synonyms:
(4-(2-(benzylamino)-7- ((1r,4r)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1-yl)(2,6- dimethylpyridin-4- yl)methanone | US11001586, Example 73
Type:
Small organic molecule
Emp. Form.:
C32H38N6O2
Mol. Mass.:
538.6831
SMILES:
Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCc3ccccc3)ncc12 |r,wU:19.20,wD:22.24,(7.78,8.63,;7.3,7.16,;5.8,6.84,;5.32,5.38,;6.35,4.23,;7.86,4.55,;8.89,3.41,;8.33,6.02,;3.82,5.06,;2.78,6.2,;3.34,3.59,;4.37,2.45,;3.89,.98,;2.39,.66,;1.36,1.81,;1.83,3.27,;1.91,-.8,;2.82,-2.05,;1.91,-3.29,;2.68,-4.63,;4.22,-4.63,;4.99,-5.96,;4.22,-7.29,;4.99,-8.63,;2.68,-7.29,;1.91,-5.96,;.45,-2.82,;-.89,-3.59,;-2.22,-2.82,;-3.55,-3.59,;-4.89,-2.82,;-6.22,-3.59,;-7.56,-2.82,;-8.89,-3.59,;-8.89,-5.13,;-7.56,-5.9,;-6.22,-5.13,;-2.22,-1.28,;-.89,-.51,;.45,-1.28,)|
Structure:
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