Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497296
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497296
Synonyms:
(2,6-dimethylpyridin-4- yl)(4-(2-(((S)-1-(4- fluorophenyl)ethyl)amino)- 7-((1r,4S)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1- yl)methanone | US11001586, Example 75
Type:
Small organic molecule
Emp. Form.:
C33H39FN6O2
Mol. Mass.:
570.7002
SMILES:
C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1)c1ccc(F)cc1 |r,wU:10.9,wD:13.13,1.0,(-4.22,-1.28,;-4.22,-2.82,;-2.89,-3.59,;-1.55,-2.82,;-1.55,-1.28,;-.22,-.51,;1.11,-1.28,;2.58,-.8,;3.48,-2.05,;2.58,-3.29,;3.35,-4.63,;4.89,-4.63,;5.66,-5.96,;4.89,-7.29,;5.66,-8.63,;3.35,-7.29,;2.58,-5.96,;1.11,-2.82,;-.22,-3.59,;3.05,.66,;4.56,.98,;5.04,2.45,;4.01,3.59,;2.5,3.27,;2.02,1.81,;4.48,5.06,;3.45,6.2,;5.99,5.38,;6.46,6.84,;7.97,7.16,;8.45,8.63,;9,6.02,;8.53,4.55,;9.56,3.41,;7.02,4.23,;-5.55,-3.59,;-6.89,-2.82,;-8.22,-3.59,;-8.22,-5.13,;-9.56,-5.9,;-6.89,-5.9,;-5.55,-5.13,)|
Structure:
Search PDB for entries with ligand similarity: