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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497298
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497298
Synonyms:
(4-(2-(((R)-2,3-dihydro-1H- inden-1-yl)amino)-7- ((1r,4R)-4- hydroxycyclohexyl)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1-yl)(2,6- dimethylpyridin-4- yl)methanone | US11001586, Example 77
Type:
Small organic molecule
Emp. Form.:
C34H40N6O2
Mol. Mass.:
564.7204
SMILES:
Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(N[C@@H]3CCc4ccccc34)ncc12 |r,wU:30.32,19.20,wD:22.24,(7.99,8.63,;7.51,7.16,;6.01,6.84,;5.53,5.38,;6.56,4.23,;8.07,4.55,;9.1,3.41,;8.54,6.02,;4.02,5.06,;2.99,6.2,;3.55,3.59,;4.58,2.45,;4.1,.98,;2.6,.66,;1.57,1.81,;2.04,3.27,;2.12,-.8,;3.03,-2.05,;2.12,-3.29,;2.89,-4.63,;4.43,-4.63,;5.2,-5.96,;4.43,-7.29,;5.2,-8.63,;2.89,-7.29,;2.12,-5.96,;.66,-2.82,;-.68,-3.59,;-2.01,-2.82,;-3.34,-3.59,;-4.68,-2.82,;-4.84,-1.29,;-6.35,-.96,;-7.12,-2.3,;-8.62,-2.62,;-9.1,-4.08,;-8.07,-5.23,;-6.56,-4.91,;-6.09,-3.44,;-2.01,-1.28,;-.68,-.51,;.66,-1.28,)|
Structure:
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