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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497301
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<3±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497301
Synonyms:
(3,5-dimethoxyphenyl)(4- (7-((1r,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)methanone | US11001586, Example 80
Type:
Small organic molecule
Emp. Form.:
C31H43N5O4
Mol. Mass.:
549.7042
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(OC)cc(OC)c1 |r,wU:13.12,wD:16.16,3.3,(-9.64,-3.48,;-8.31,-2.71,;-6.97,-3.48,;-5.64,-2.71,;-5.64,-1.17,;-4.31,-3.48,;-2.97,-2.71,;-2.97,-1.17,;-1.64,-.4,;-.31,-1.17,;1.16,-.7,;2.06,-1.94,;1.16,-3.19,;1.63,-4.66,;3.14,-4.98,;3.62,-6.44,;2.59,-7.58,;3.06,-9.05,;1.08,-7.26,;.6,-5.8,;-.31,-2.71,;-1.64,-3.48,;1.63,.77,;3.14,1.09,;3.62,2.55,;2.59,3.69,;1.08,3.37,;.6,1.91,;3.06,5.16,;2.03,6.3,;4.57,5.48,;5.04,6.94,;6.55,7.26,;7.03,8.73,;8.53,9.05,;7.58,6.12,;7.11,4.66,;8.14,3.51,;9.64,3.83,;5.6,4.34,)|
Structure:
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