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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497310
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<3±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497310
Synonyms:
(4-(7-((1r,4S)-4- (difluoromethyl)cyclohexyl)- 2-(((S)-pentan-2- yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(2,6-dimethylpyridin- 4-yl)methanone | US11001586, Example 88
Type:
Small organic molecule
Emp. Form.:
C31H42F2N6O
Mol. Mass.:
552.7016
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@@H](CC3)C(F)F)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wU:13.12,wD:3.3,16.19,(-8.89,-2.75,;-7.56,-1.98,;-6.22,-2.75,;-4.89,-1.98,;-4.89,-.44,;-3.55,-2.75,;-2.22,-1.98,;-2.22,-.44,;-.89,.33,;.45,-.44,;1.91,.03,;2.82,-1.21,;1.91,-2.46,;2.39,-3.92,;3.89,-4.24,;4.37,-5.71,;3.36,-6.9,;1.83,-6.53,;1.36,-5.07,;3.83,-8.37,;5.34,-8.69,;2.8,-9.51,;.45,-1.98,;-.89,-2.75,;2.39,1.5,;3.89,1.82,;4.37,3.28,;3.34,4.43,;1.83,4.11,;1.36,2.64,;3.82,5.89,;2.78,7.04,;5.32,6.21,;5.8,7.68,;7.3,8,;7.78,9.46,;8.33,6.85,;7.86,5.39,;8.89,4.24,;6.35,5.07,)|
Structure:
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