Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497314
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
275±n/a nM
Citation
 Wang, XZheng, HZhao, JZhang, WFrye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497314
Synonyms:
(1S,4r)-4-(5-(1- (cyclohexylmethyl)piperidin- 4-yl)-2-(((S)-1- phenylethyl)amino)-7H- pyrrolo[2,3-d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 92
Type:
Small organic molecule
Emp. Form.:
C32H45N5O
Mol. Mass.:
515.7326
SMILES:
C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCCCC2)CC1)c1ccccc1 |r,wU:13.13,1.0,wD:10.9,(5.71,-.54,;5.71,-2.08,;4.38,-2.85,;3.04,-2.08,;3.04,-.54,;1.71,.23,;.38,-.54,;-1.09,-.07,;-1.99,-1.31,;-1.09,-2.56,;-1.56,-4.02,;-3.07,-4.34,;-3.55,-5.81,;-2.51,-6.95,;-2.99,-8.42,;-1.01,-6.63,;-.53,-5.17,;.38,-2.08,;1.71,-2.85,;-1.56,1.4,;-3.07,1.72,;-3.55,3.18,;-2.51,4.33,;-2.99,5.79,;-1.96,6.94,;-2.44,8.4,;-1.41,9.55,;.1,9.22,;.58,7.76,;-.45,6.62,;-1.01,4.01,;-.53,2.54,;7.05,-2.85,;8.38,-2.08,;9.71,-2.85,;9.71,-4.39,;8.38,-5.16,;7.05,-4.39,)|
Structure:
Search PDB for entries with ligand similarity: