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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497324
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
275±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497324
Synonyms:
(4-(7-(((1r,4S)-4- aminocyclohexyl)methyl)- 2-(((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)(2,6-dimethylpyridin- 4-yl)methanone | US11001586, Example 102
Type:
Small organic molecule
Emp. Form.:
C31H45N7O
Mol. Mass.:
531.7353
SMILES:
CCC[C@H](C)Nc1ncc2c(cn(CC3CC[C@H](N)CC3)c2n1)C1CCN(CC1)C(=O)c1cc(C)nc(C)c1 |r,wD:3.3,17.17,(-8.89,-3.23,;-7.56,-2.46,;-6.22,-3.23,;-4.89,-2.46,;-4.89,-.92,;-3.55,-3.23,;-2.22,-2.46,;-2.22,-.92,;-.89,-.15,;.45,-.92,;1.91,-.45,;2.82,-1.69,;1.91,-2.94,;2.39,-4.4,;1.36,-5.55,;1.83,-7.01,;.8,-8.16,;-.7,-7.84,;-1.73,-8.98,;-1.18,-6.37,;-.15,-5.23,;.45,-2.46,;-.89,-3.23,;2.39,1.02,;3.89,1.34,;4.37,2.8,;3.34,3.95,;1.83,3.63,;1.36,2.16,;3.82,5.41,;2.78,6.56,;5.32,5.73,;5.8,7.2,;7.3,7.52,;7.78,8.98,;8.33,6.37,;7.86,4.91,;8.89,3.76,;6.35,4.59,)|
Structure:
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