Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM497382
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Disubstituted compounds for treatment of medical disorders US Patent  US11001600 Publication Date 5/11/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM497382
Synonyms:
(2S,4R)-1-(2-(3- acetyl-6-(2- (dimethylamino) ethoxy)-5-(2- methylpyrimidin-5- yl)-1H-indazol-1- yl)acetyl)-N-(6- bromopyridin-2- yl)-4- fluoropyrrolidine- 2-carboxamide | US11001600, Cmp No. 44
Type:
Small organic molecule
Emp. Form.:
C30H32BrFN8O4
Mol. Mass.:
667.529
SMILES:
CN(C)CCOc1cc2n(CC(=O)N3C[C@H](F)C[C@H]3C(=O)Nc3cccc(Br)n3)nc(C(C)=O)c2cc1-c1cnc(C)nc1 |r|
Structure:
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