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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM497387
Substrate
n/a
Meas. Tech.
Pharmacological Activity Assay
Ki
217±n/a nM
Citation
 Godek, DM; Howard, HR; Stewart, AM Cycloalkyl-diamines for the treatment of pain US Patent  US11007200 Publication Date 5/18/2021 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM497387
Synonyms:
US11007200, Example 3b | US11426411, Example 3b
Type:
Small organic molecule
Emp. Form.:
C22H28ClFN2
Mol. Mass.:
374.923
SMILES:
CN[C@]1(CCCC[C@@H]1NCCCc1ccc(F)cc1)c1ccccc1Cl
Structure:
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