Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM497389
Substrate
n/a
Ki
426±n/a nM
Citation
 Godek, DM; Howard, HR; Stewart, AM Cycloalkyl-diamines for the treatment of pain US Patent  US11007200 Publication Date 5/18/2021 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM497389
Synonyms:
US11007200, Example 4b | US11426411, Example 4b
Type:
Small organic molecule
Emp. Form.:
C22H29ClN2
Mol. Mass.:
356.932
SMILES:
CN[C@]1(CCCC[C@@H]1NCCCc1ccccc1)c1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: