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TargetNuclear receptor ROR-gamma (RORC)
LigandBDBM498079
Substrate/Competitorn/a
Meas. Tech.Receptor Competition Binding Assay
Ki 3.27±1.09 nM
Citation Clarke, CALugar, III, CWMorphy, JRRichardson, TIRudyk, HSapmaz, SStites, REVaught, GM Compounds useful for inhibiting RORγt US Patent US11008336 Publication Date 5/18/2021
More Info.:Get all data from this article,  Assay Method
 
Nuclear receptor ROR-gamma (RORC)
Name:Nuclear receptor ROR-gamma (RORC)
Synonyms:NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:Enzyme Catalytic Domain
Mol. Mass.:58218.40
Organism:Homo sapiens (Human)
Description:P51449
Residue:518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM498079
NameBDBM498079
Synonyms:(5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-5'- methyl-1-{1-[2- (trifluoromethyl)-1,3- thiazol-5-yl]ethyl}- 4',5'- dihydrospiro[piperidine- 4,7'-thieno[2,3- c]pyran]-2'- carboxamide isomer 2 | US11008336, Example 55
TypeSmall organic molecule
Emp. Form.C27H31F3N4O4S3
Mol. Mass.628.75
SMILESCCS(=O)(=O)c1ccc(CNC(=O)c2cc3C[C@H](C)OC4(CCN(CC4)C(C)c4cnc(s4)C(F)(F)F)c3s2)nc1 |r|
Structure
n/a