Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM466573
Substrate
n/a
Meas. Tech.
Binding Activity Assay
Ki
2474±n/a nM
Citation
 Yoshinaga, H; Uemachi, H; Ohno, T; Besnard, J 2,6-disubstituted pyridine derivative US Patent  US11014905 Publication Date 5/25/2021 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM466573
Synonyms:
US10800755, Example 27 | US11014905, Example 27
Type:
Small organic molecule
Emp. Form.:
C21H30F3N3O2
Mol. Mass.:
413.477
SMILES:
CO[C@H]1CC[C@@H](CC1)C(=O)NCCN1CCC(CC1)c1cccc(n1)C(F)(F)F |r,wU:2.1,wD:5.8,(-9.74,5.37,;-10,3.85,;-8.67,3.08,;-7.34,3.85,;-6,3.08,;-6,1.54,;-7.34,.77,;-8.67,1.54,;-4.67,.77,;-4.67,-.77,;-3.33,1.54,;-2,.77,;-.67,1.54,;.67,.77,;.67,-.77,;2,-1.54,;3.33,-.77,;3.33,.77,;2,1.54,;4.67,-1.54,;4.67,-3.08,;6,-3.85,;7.34,-3.08,;7.38,-1.51,;6,-.77,;8.72,-.74,;10.05,.03,;7.95,.59,;9.49,-2.08,)|
Structure:
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