Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM160920
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
120±n/a nM
Citation
 Brodney, MA; Davoren, JE; Dounay, AB; Efremov, IV; Gray, DL; Green, ME; Henderson, JL; Lee, C; Mente, SR; O''Neil, SV; Rogers, BN; Zhang, L Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US11014909 Publication Date 5/25/2021 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM160920
Synonyms:
US11014909, Example 10 | US9107923, 10 | US9107923, 9
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3O3
Mol. Mass.:
371.818
SMILES:
Cc1cnc(Oc2ccc(c(C)c2)-c2c(C)c(=O)[nH]c(=O)n2C)c(Cl)c1 |(-8,1.54,;-8,,;-6.67,-.77,;-6.67,-2.31,;-8,-3.08,;-8,-4.62,;-6.67,-5.39,;-5.33,-4.62,;-4,-5.39,;-4,-6.93,;-5.33,-7.7,;-5.33,-9.24,;-6.67,-6.93,;-2.67,-7.7,;-1.33,-6.93,;-1.33,-5.39,;,-7.7,;1.33,-6.93,;,-9.24,;-1.33,-10.01,;-1.33,-11.55,;-2.67,-9.24,;-4,-10.01,;-9.34,-2.31,;-10.67,-3.08,;-9.34,-.77,)|
Structure:
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