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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM498707
Substrate
n/a
Meas. Tech.
Biochemical Assay
Ki
1.41±n/a nM
Citation
 Behenna, DC; Freeman-Cook, KD; Hoffman, RL; Nagata, A; Ninkovic, S; Sutton, SC CDK2 inhibitors US Patent  US11014911 Publication Date 5/25/2021 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM498707
Synonyms:
(1R,3S)-3-(3-{[(6- methoxypyridin-3- yl)acetyl]amino}-1H-pyrazol-5- yl)cyclopentyl [(2$#958;)-2- (hydroxymethyl)butyl] carbamate - Isomer A | US11014911, Example 532 | US11014911, Example 533 | US11718603, Example 533
Type:
Small organic molecule
Emp. Form.:
C22H31N5O5
Mol. Mass.:
445.512
SMILES:
CCC(CO)CNC(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2ccc(OC)nc2)n[nH]1 |r|
Structure:
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