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Target
Protein mono-ADP-ribosyltransferase TIPARP
Ligand
BDBM431706
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<100±n/a nM
Citation
 Vasbinder, MM; Schenkel, LB; Swinger, KK; Kuntz, KW Pyridazinones as PARP7 inhibitors US Patent  US11014913 Publication Date 5/25/2021 
Target
Name:
Protein mono-ADP-ribosyltransferase TIPARP
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 14 | ARTD14 | PARP-7 | PARP7 | PARPT_HUMAN | Poly [ADP-ribose] polymerase 7 | TCDD-inducible poly [ADP-ribose] polymerase | TIPARP
Type:
Protein
Mol. Mass.:
76228.44
Organism:
Human
Description:
Q7Z3E1
Residue:
657
Sequence:
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
  
Inhibitor
Name:
BDBM431706
Synonyms:
US10550105, Example 583A | US10870641, Example 583A | US11014913, Example 583A
Type:
Small organic molecule
Emp. Form.:
C23H25F3N6O4
Mol. Mass.:
506.4776
SMILES:
FC(F)(F)c1c(OC[C@@H]2CCC[C@@H](CC(=O)N3CCN(CC3)c3ccc(cn3)C#N)O2)cn[nH]c1=O |r|
Structure:
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