Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM499484
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
7.50±n/a nM
Citation
Chen, Y; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Ramsden, PD Cycloalkyl substituted triazole compounds as agonists of the APJ receptor US Patent US11020395 Publication Date 6/1/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM499484
Synonyms:
US11020395, Example 6.0
Type:
Small organic molecule
Emp. Form.:
C22H29ClN8O5S
Mol. Mass.:
553.034
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(C2CCCCC2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,(2.54,-4.26,;3.63,-3.17,;3.63,-1.63,;2.3,-.86,;2.3,.68,;.97,-1.63,;-.37,-2.4,;2.3,-2.4,;-.37,-.86,;-1.86,-1.26,;-2.33,-2.73,;-3.87,-2.73,;-4.35,-1.26,;-5.89,-1.26,;-6.66,.07,;-8.2,.07,;-8.97,-1.26,;-8.2,-2.6,;-6.66,-2.6,;-3.1,-.36,;-3.1,1.18,;-1.77,1.95,;-.43,1.18,;.9,1.95,;-1.77,3.49,;-3.1,4.26,;-4.44,3.49,;-4.44,1.95,;-5.77,1.18,;-7.1,1.95,;4.97,-.86,;6.3,-1.63,;7.63,-.86,;7.63,.68,;8.97,1.45,;6.3,1.45,;4.97,.68,)|