Target
Apelin receptor
Ligand
BDBM499516
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
140±n/a nM
Citation
 Chen, YDransfield, PJHarvey, JSHeath, JAHouze, JKhakoo, AYKopecky, DJLai, SMa, ZNishimura, NPattaropong, VSwaminath, GYeh, WRamsden, PD Cycloalkyl substituted triazole compounds as agonists of the APJ receptor US Patent  US11020395 Publication Date 6/1/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM499516
Synonyms:
US11020395, Example 100.0 | US11020395, Example 101.0
Type:
Small organic molecule
Emp. Form.:
C19H21ClF2N8O5S
Mol. Mass.:
546.935
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC2(F)F)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(4.76,.83,;3.43,1.6,;3.43,3.14,;2.09,3.91,;2.09,5.45,;.76,3.14,;-.01,1.81,;1.53,1.81,;-.57,3.91,;-1.91,3.14,;-2.38,1.67,;-3.92,1.67,;-4.4,3.14,;-5.94,3.14,;-7.27,3.91,;-7.27,2.37,;-8.76,1.97,;-6.88,.88,;-3.15,4.04,;-3.15,5.58,;-4.49,6.35,;-5.82,5.58,;-7.16,6.35,;-4.49,7.89,;-3.15,8.66,;-1.82,7.89,;-1.82,6.35,;-.49,5.58,;.85,6.35,;4.76,3.91,;6.09,3.14,;7.43,3.91,;7.43,5.45,;8.76,6.22,;6.09,6.22,;4.76,5.45,)|
Structure:
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