Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM499536
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
120±n/a nM
Citation
Chen, Y; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Ramsden, PD Cycloalkyl substituted triazole compounds as agonists of the APJ receptor US Patent US11020395 Publication Date 6/1/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM499536
Synonyms:
US11020395, Example 132.0 | US11020395, Example 133.0
Type:
Small organic molecule
Emp. Form.:
C20H29ClN6O5S
Mol. Mass.:
500.999
SMILES:
COCC1(CC1)n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(Cl)cn2)nnc1[C@H]1C[C@H](CO)C1 |r,wU:12.13,29.32,14.15,wD:27.29,(2.68,-.78,;1.5,-1.77,;1.77,-3.28,;.59,-4.27,;1.36,-5.61,;-.18,-5.61,;-.59,-3.28,;-.48,-1.75,;.83,-.93,;.77,.61,;-.77,.55,;2.31,.66,;.72,2.15,;-.64,2.87,;2.02,2.96,;3.38,2.24,;4.69,3.06,;1.97,4.5,;.61,5.22,;.56,6.76,;1.86,7.58,;1.81,9.12,;3.22,6.86,;3.28,5.32,;-1.91,-1.17,;-2.9,-2.35,;-2.08,-3.66,;-2.66,-5.08,;-4.08,-5.69,;-3.47,-7.1,;-4.05,-8.53,;-3.1,-9.75,;-2.06,-6.5,)|