Target
Apelin receptor
Ligand
BDBM499567
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
0.540±n/a nM
Citation
 Chen, YDransfield, PJHarvey, JSHeath, JAHouze, JKhakoo, AYKopecky, DJLai, SMa, ZNishimura, NPattaropong, VSwaminath, GYeh, WRamsden, PD Cycloalkyl substituted triazole compounds as agonists of the APJ receptor US Patent  US11020395 Publication Date 6/1/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM499567
Synonyms:
US11020395, Example 164.0 | US11020395, Example 165.0
Type:
Small organic molecule
Emp. Form.:
C20H24Cl2N8O5S
Mol. Mass.:
559.426
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@@H]2C[C@H](Cl)C2)n1-c1c(OC)ncnc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,15.15,(2.26,4.6,;1.35,3.36,;-.18,3.52,;-1.08,2.27,;-2.61,2.43,;-.46,.87,;-1.86,.24,;.95,1.49,;.17,-.54,;-.73,-1.79,;-2.27,-1.79,;-2.75,-3.25,;-1.5,-4.16,;-1.5,-5.7,;-.42,-6.79,;-1.5,-7.87,;-1.5,-9.41,;-2.59,-6.79,;-.26,-3.25,;1.21,-3.73,;2.35,-2.7,;2.03,-1.19,;3.17,-.16,;3.81,-3.17,;4.14,-4.68,;2.99,-5.71,;1.53,-5.23,;.38,-6.26,;-.98,-5.54,;-.8,4.93,;-2.34,5.09,;-2.96,6.49,;-2.06,7.74,;-2.68,9.15,;-.52,7.58,;.1,6.17,)|
Structure:
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