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Target
Apelin receptor
Ligand
BDBM499622
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
1.20±n/a nM
Citation
 Chen, Y; Dransfield, PJ; Harvey, JS; Heath, JA; Houze, J; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Nishimura, N; Pattaropong, V; Swaminath, G; Yeh, W; Ramsden, PD Cycloalkyl substituted triazole compounds as agonists of the APJ receptor US Patent  US11020395 Publication Date 6/1/2021 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM499622
Synonyms:
US11020395, Example 222.0 | US11020395, Example 223.0
Type:
Small organic molecule
Emp. Form.:
C23H27ClN6O5S
Mol. Mass.:
535.016
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc([C@H]2CC22CC2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1 |r,wU:3.3,2.1,wD:13.12,(3.69,1.17,;2.6,2.25,;3,3.74,;1.91,4.83,;2.31,6.32,;.43,4.43,;-1.06,4.03,;1.51,3.34,;-.66,5.52,;-2.15,5.12,;-2.63,3.66,;-4.17,3.66,;-4.64,5.12,;-5.98,5.89,;-7.07,6.98,;-7.46,5.49,;-8.95,5.1,;-7.86,4.01,;-3.4,6.03,;-3.4,7.57,;-4.73,8.34,;-6.06,7.57,;-7.4,8.34,;-4.73,9.88,;-3.4,10.65,;-2.06,9.88,;-2.06,8.34,;-.73,7.57,;.6,8.34,;4.49,4.14,;5.58,3.05,;7.07,3.45,;7.46,4.94,;8.95,5.34,;6.38,6.03,;4.89,5.63,)|
Structure:
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