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Target
Tyrosine-protein kinase BTK
Ligand
BDBM499891
Substrate
n/a
Meas. Tech.
Mobility Shift Assay (MSA) Type B
IC50
1.40±n/a nM
Citation
 Bates, C; Eathiraj, S; Inagaki, H; Lapierre, J; Momose, T; Nakayama, K; Odagiri, T; Ota, M; Ota, Y; Shibata, Y; Tandon, M; Tsunemi, T Amino-pyrrolopyrimidinone compounds and methods of use thereof US Patent  US11020398 Publication Date 6/1/2021 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM499891
Synonyms:
2-hydroxy-2-methyl-N-(cis-4-((5-(4- phenoxybenzoyl)-7H-pyrrolo[2,3- d]pyrimidin-4- yl)amino)cyclohexyl)propanamide | US11020398, Compound I-203
Type:
Small organic molecule
Emp. Form.:
C29H31N5O4
Mol. Mass.:
513.5875
SMILES:
CC(C)(O)C(=O)N[C@H]1CC[C@H](CC1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3)c12 |r,wU:7.6,10.13,(-10.51,4.52,;-9.74,3.18,;-8.97,4.52,;-11.07,2.41,;-8.41,2.41,;-8.41,.87,;-7.07,3.18,;-5.74,2.41,;-4.41,3.18,;-3.07,2.41,;-3.07,.87,;-4.41,.1,;-5.74,.87,;-1.74,.1,;-1.74,-1.44,;-3.07,-2.21,;-3.07,-3.75,;-1.74,-4.52,;-.4,-3.75,;1.06,-4.22,;1.97,-2.98,;1.06,-1.73,;1.46,-.24,;.37,.85,;2.95,.16,;4.03,-.93,;5.52,-.54,;5.92,.95,;7.41,1.35,;8.5,.26,;8.1,-1.23,;9.19,-2.31,;10.68,-1.92,;11.07,-.43,;9.99,.66,;4.83,2.04,;3.34,1.64,;-.4,-2.21,)|
Structure:
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