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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM499992
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM499992
Synonyms:
US11021457, Compound 1
Type:
Small organic molecule
Emp. Form.:
C34H37N5O6
Mol. Mass.:
611.6875
SMILES:
O=C(Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)C1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1 |(7.41,-1.14,;6.17,-.23,;6.33,1.3,;5.08,2.21,;3.67,1.58,;2.43,2.48,;2.59,4.02,;4,4.64,;4.47,6.11,;3.57,7.35,;6.01,6.11,;6.49,4.64,;5.24,3.74,;6.92,7.35,;6.29,8.76,;7.2,10.01,;8.73,9.84,;9.63,11.09,;9.35,8.44,;8.45,7.19,;9.07,5.78,;4.76,-.86,;3.51,.05,;2.11,-.58,;1.94,-2.11,;.54,-2.74,;.38,-4.27,;-1.03,-4.9,;-1.19,-6.43,;-2.6,-7.05,;-3.84,-6.15,;-3.68,-4.62,;-5.25,-6.77,;-5.41,-8.31,;-4.17,-9.21,;-2.76,-8.58,;-1.51,-9.49,;-6.82,-8.93,;-8.06,-8.03,;-9.47,-8.65,;-9.63,-10.18,;-8.39,-11.09,;-6.98,-10.46,;3.19,-3.02,;4.6,-2.39,)|
Structure:
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