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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500012
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500012
Synonyms:
US11021457, Compound 16
Type:
Small organic molecule
Emp. Form.:
C29H22BrF3N4O5
Mol. Mass.:
643.408
SMILES:
FC(F)(F)c1c[nH]c2ccc(Br)c(C3CC(=O)C(=CNc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)C(=O)C3)c12 |(.82,-2.12,;.34,-3.58,;1.81,-4.06,;-1.12,-3.11,;-.13,-5.05,;.77,-6.29,;-.13,-7.54,;-1.6,-7.06,;-2.93,-7.83,;-4.26,-7.06,;-4.26,-5.52,;-5.6,-4.75,;-2.93,-4.75,;-2.93,-3.21,;-4.26,-2.44,;-4.26,-.9,;-5.6,-.13,;-2.93,-.13,;-2.93,1.41,;-4.26,2.18,;-4.26,3.72,;-5.6,4.49,;-5.6,6.03,;-4.26,6.8,;-2.93,6.03,;-1.47,6.5,;-.7,7.83,;-.56,5.26,;-1.47,4.01,;-2.93,4.49,;.98,5.26,;1.75,6.59,;3.29,6.59,;4.06,5.26,;5.6,5.26,;3.29,3.92,;1.75,3.92,;.98,2.59,;-1.6,-.9,;-.26,-.13,;-1.6,-2.44,;-1.6,-5.52,)|
Structure:
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