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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500028
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500028
Synonyms:
US11021457, Compound 32
Type:
Small organic molecule
Emp. Form.:
C27H25N3O6
Mol. Mass.:
487.5039
SMILES:
COc1ccc(cc1)C1CC(=O)C(=CNc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)C(=O)C1 |(-1.6,-9.09,;-2.93,-8.32,;-2.93,-6.78,;-4.26,-5.95,;-4.26,-4.41,;-2.93,-3.64,;-1.6,-4.41,;-1.6,-5.95,;-2.93,-2.1,;-4.26,-1.33,;-4.26,.21,;-5.6,.98,;-2.93,.98,;-2.93,2.52,;-4.26,3.29,;-4.26,4.83,;-5.6,5.6,;-5.6,7.14,;-4.26,7.91,;-2.93,7.14,;-1.47,7.61,;-.7,8.95,;-.56,6.37,;-1.47,5.12,;-2.93,5.6,;.98,6.37,;1.75,5.03,;3.29,5.03,;4.06,6.37,;5.6,6.37,;3.29,7.7,;1.75,7.7,;.98,9.03,;-1.6,.21,;-.26,.98,;-1.6,-1.33,)|
Structure:
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