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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500033
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500033
Synonyms:
US11021457, Compound 37
Type:
Small organic molecule
Emp. Form.:
C28H23N3O5S
Mol. Mass.:
513.564
SMILES:
O=C1N(Cc2c1cccc2NC=C1C(=O)CC(CC1=O)c1csc2ccccc12)C1CCC(=O)NC1=O |(-.7,8.01,;-1.47,6.67,;-.56,5.43,;-1.47,4.18,;-2.93,4.66,;-2.93,6.2,;-4.26,6.97,;-5.6,6.2,;-5.6,4.66,;-4.26,3.89,;-4.26,2.35,;-2.93,1.58,;-2.93,.04,;-4.26,-.73,;-5.6,.04,;-4.26,-2.27,;-2.93,-3.04,;-1.6,-2.27,;-1.6,-.73,;-.26,.04,;-2.93,-4.58,;-4.18,-5.49,;-3.7,-6.95,;-2.16,-6.95,;-1.13,-8.1,;.38,-7.78,;.85,-6.31,;-.18,-5.17,;-1.69,-5.49,;.98,5.43,;1.75,4.09,;3.29,4.09,;4.06,5.43,;5.6,5.43,;3.29,6.76,;1.75,6.76,;.98,8.1,)|
Structure:
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