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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500051
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500051
Synonyms:
US11021457, Compound 55
Type:
Small organic molecule
Emp. Form.:
C34H36N6O7
Mol. Mass.:
640.6856
SMILES:
O=C(CN1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12 |(-8.67,3.29,;-7.34,2.52,;-7.34,.98,;-6,.21,;-6,-1.33,;-4.67,-2.1,;-3.33,-1.33,;-2,-2.1,;-2,-3.64,;-.67,-4.41,;.67,-3.64,;2,-4.41,;2,-5.95,;.67,-6.72,;3.33,-6.72,;4.67,-5.95,;4.67,-4.41,;3.33,-3.64,;3.33,-2.1,;6,-6.72,;6,-8.26,;7.34,-9.03,;8.67,-8.26,;8.67,-6.72,;7.34,-5.95,;-3.33,.21,;-4.67,.98,;-6,3.29,;-6,4.83,;-7.34,5.6,;-7.34,7.14,;-6,7.91,;-4.67,7.14,;-3.2,7.61,;-2.43,8.95,;-2.3,6.37,;-.76,6.37,;.01,5.03,;1.55,5.03,;2.32,6.37,;3.86,6.37,;1.55,7.7,;.01,7.7,;-.76,9.03,;-3.2,5.12,;-2.43,3.79,;-4.67,5.6,)|
Structure:
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