Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500061
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, ZLuo, CXie, YYue, LWan, WZhang, YJiang, HChen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500061
Synonyms:
US11021457, Compound 65
Type:
Small organic molecule
Emp. Form.:
C33H35N5O7
Mol. Mass.:
613.6603
SMILES:
O[C@H]1C[C@H](N(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)C1)C(=O)Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O |r,wU:3.26,1.0,(-8.43,-5.46,;-7.66,-4.12,;-8.14,-2.66,;-6.89,-1.75,;-5.65,-2.66,;-4.16,-2.26,;-3.07,-3.35,;-1.58,-2.95,;-.49,-4.04,;.99,-3.64,;1.39,-2.15,;.3,-1.06,;2.88,-1.75,;3.97,-2.84,;3.57,-4.33,;2.08,-4.73,;1.68,-6.22,;5.46,-2.44,;6.55,-3.53,;8.03,-3.13,;8.43,-1.65,;7.34,-.56,;5.86,-.96,;-6.12,-4.12,;-6.89,-.21,;-8.23,.56,;-5.56,.56,;-5.56,2.1,;-6.89,2.87,;-6.89,4.41,;-5.56,5.18,;-4.22,4.41,;-2.76,4.88,;-1.99,6.22,;-1.85,3.64,;-2.76,2.39,;-4.22,2.87,;-.31,3.64,;.46,4.97,;2,4.97,;2.77,3.64,;4.31,3.64,;2,2.3,;.46,2.3,;-.31,.97,)|
Structure:
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