Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500077
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500077
Synonyms:
US11021457, Compound 84
Type:
Small organic molecule
Emp. Form.:
C31H27N5O7S
Mol. Mass.:
613.64
SMILES:
O=C(Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)OCc1cnc(NC=C2C(=O)CC(CC2=O)c2ccccc2)s1 |(-.18,-7.57,;-.18,-6.03,;1.15,-5.26,;1.15,-3.72,;-.18,-2.95,;-.18,-1.41,;1.15,-.64,;2.48,-1.41,;3.95,-.93,;4.35,.55,;4.85,-2.18,;3.95,-3.42,;2.48,-2.95,;6.39,-2.18,;7.16,-3.51,;8.7,-3.51,;9.47,-2.18,;11.01,-2.18,;8.7,-.84,;7.16,-.84,;6.39,.49,;-1.52,-5.26,;-2.85,-6.03,;-4.18,-5.26,;-5.65,-5.73,;-6.55,-4.49,;-5.65,-3.24,;-6.05,-1.76,;-7.53,-1.36,;-7.93,.13,;-6.84,1.22,;-5.36,.82,;-7.24,2.71,;-8.73,3.11,;-9.82,2.02,;-9.42,.53,;-10.51,-.56,;-9.13,4.59,;-10.62,4.99,;-11.01,6.48,;-9.93,7.57,;-8.44,7.17,;-8.04,5.68,;-4.18,-3.72,)|
Structure:
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