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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500083
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500083
Synonyms:
US11021457, Compound 90
Type:
Small organic molecule
Emp. Form.:
C53H65N11O11
Mol. Mass.:
1032.1503
SMILES:
CC(C)[C@H](NC(=O)CN1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Nc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)cc1 |r,wD:35.37,3.3,(7.34,-3.29,;6,-2.52,;4.67,-3.29,;6,-.98,;4.67,-.21,;3.33,-.98,;2,-.21,;3.33,-2.52,;2,-3.29,;.67,-2.52,;-.67,-3.29,;-.67,-4.83,;-2,-5.6,;-3.33,-4.83,;-4.67,-5.6,;-6,-4.83,;-7.34,-5.6,;-8.67,-4.83,;-8.67,-3.29,;-10,-5.6,;-10,-7.14,;-8.67,-7.91,;-7.34,-7.14,;-6,-7.91,;-11.34,-7.91,;-12.67,-7.14,;-14,-7.91,;-14,-9.45,;-12.67,-10.22,;-11.34,-9.45,;.67,-5.6,;2,-4.83,;7.34,-.21,;8.67,-.98,;7.34,1.33,;8.67,2.1,;10,1.33,;10,-.21,;11.34,-.98,;11.34,-2.52,;12.67,-3.29,;12.67,-4.83,;14,-2.52,;8.67,3.64,;10,4.41,;7.34,4.41,;6,3.64,;6,2.1,;4.67,1.33,;3.33,2.1,;2,1.33,;.67,2.1,;.67,3.64,;2,4.41,;-.67,4.41,;-.67,5.95,;-2,6.72,;-2,8.26,;-.67,9.03,;.67,8.26,;2.13,8.73,;2.53,10.22,;3.04,7.49,;2.13,6.24,;.67,6.72,;4.58,7.49,;5.35,6.15,;6.89,6.15,;7.66,7.49,;9.2,7.49,;6.89,8.82,;5.35,8.82,;4.58,10.16,;3.33,3.64,;4.67,4.41,)|
Structure:
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