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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500087
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500087
Synonyms:
US11021457, Compound 94
Type:
Small organic molecule
Emp. Form.:
C40H40N6O7
Mol. Mass.:
716.7816
SMILES:
O=C(Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)c1ccc(CN2CCN(CCNC=C3C(=O)CC(CC3=O)c3ccccc3)CC2)cc1 |(3.07,-5.77,;3.07,-4.23,;4.4,-3.46,;4.4,-1.92,;3.07,-1.15,;3.07,.39,;4.4,1.16,;5.74,.39,;7.2,.86,;7.6,2.35,;8.11,-.38,;9.65,-.38,;10.42,.95,;11.96,.95,;12.73,-.38,;14.27,-.38,;11.96,-1.72,;10.42,-1.72,;9.65,-3.05,;7.2,-1.63,;7.6,-3.12,;5.74,-1.15,;1.74,-3.46,;1.74,-1.92,;.4,-1.16,;-.93,-1.92,;-2.26,-1.15,;-3.6,-1.92,;-4.93,-1.15,;-6.27,-1.92,;-6.27,-3.46,;-7.6,-4.23,;-8.93,-3.46,;-10.27,-4.23,;-11.6,-3.46,;-11.6,-1.92,;-12.93,-1.15,;-14.27,-1.92,;-12.93,.39,;-11.6,1.16,;-10.27,.39,;-10.27,-1.15,;-8.93,-1.92,;-11.6,2.7,;-10.27,3.46,;-10.27,5,;-11.6,5.77,;-12.93,5,;-12.93,3.47,;-4.93,-4.23,;-3.6,-3.46,;-.93,-3.46,;.4,-4.23,)|
Structure:
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