Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500102
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<50±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500102
Synonyms:
US11021457, Compound 114
Type:
Small organic molecule
Emp. Form.:
C24H26N4O6
Mol. Mass.:
466.4864
SMILES:
CCCNC(=O)C1CC(=O)C(=CNc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)C(=O)C1 |(2.4,-5.95,;1.07,-6.72,;-.26,-5.95,;-1.6,-6.72,;-2.93,-5.95,;-4.26,-6.72,;-2.93,-4.41,;-4.26,-3.64,;-4.26,-2.1,;-5.6,-1.33,;-2.93,-1.33,;-2.93,.21,;-4.26,.98,;-4.26,2.52,;-5.6,3.29,;-5.6,4.83,;-4.26,5.6,;-2.93,4.83,;-1.47,5.3,;-.7,6.64,;-.56,4.06,;-1.47,2.81,;-2.93,3.29,;.98,4.06,;1.75,2.72,;3.29,2.72,;4.06,4.06,;5.6,4.06,;3.29,5.39,;1.75,5.39,;.98,6.72,;-1.6,-2.1,;-.26,-1.33,;-1.6,-3.64,)|
Structure:
Search PDB for entries with ligand similarity: