Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500105
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500105
Synonyms:
US11021457, Compound 117
Type:
Small organic molecule
Emp. Form.:
C31H26N4O5
Mol. Mass.:
534.5619
SMILES:
O=C1N(Cc2c1cccc2NC=C1C(=O)CC(CC1=O)c1ccc(cc1)-c1ccncc1)C1CCC(=O)NC1=O |(-.7,10.1,;-1.47,8.77,;-.56,7.52,;-1.47,6.28,;-2.93,6.75,;-2.93,8.29,;-4.26,9.06,;-5.6,8.29,;-5.6,6.75,;-4.26,5.98,;-4.26,4.44,;-2.93,3.67,;-2.93,2.13,;-4.26,1.36,;-5.6,2.13,;-4.26,-.18,;-2.93,-.95,;-1.6,-.18,;-1.6,1.36,;-.26,2.13,;-2.93,-2.49,;-4.26,-3.26,;-4.26,-4.8,;-2.93,-5.57,;-1.6,-4.8,;-1.6,-3.26,;-2.93,-7.11,;-4.26,-7.88,;-4.26,-9.42,;-2.93,-10.19,;-1.6,-9.42,;-1.6,-7.88,;.98,7.52,;1.75,6.19,;3.29,6.19,;4.06,7.52,;5.6,7.52,;3.29,8.85,;1.75,8.85,;.98,10.19,)|
Structure:
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