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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500117
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500117
Synonyms:
US11021457, Compound 129
Type:
Small organic molecule
Emp. Form.:
C41H51N5O9
Mol. Mass.:
757.8717
SMILES:
O=C1N(C2CCC(=O)CC2=O)C(=O)c2c1cccc2NCCOCCOCCOCCN1CCN(CCNC=C2C(=O)CC(CC2=O)c2ccccc2)CC1 |(-9.4,3.87,;-9.87,2.4,;-8.97,1.15,;-7.43,1.15,;-6.66,-.18,;-5.12,-.18,;-4.35,1.15,;-2.81,1.15,;-5.12,2.49,;-6.66,2.49,;-7.43,3.82,;-9.87,-.09,;-9.4,-1.56,;-11.34,.38,;-11.34,1.93,;-12.67,2.69,;-14,1.93,;-14,.38,;-12.67,-.38,;-12.67,-1.93,;-14,-2.69,;-14,-4.23,;-12.67,-5,;-11.34,-4.23,;-10,-5,;-8.67,-4.23,;-7.34,-5,;-6,-4.23,;-4.67,-5,;-3.33,-4.23,;-2,-5,;-.67,-4.23,;.67,-5,;2,-4.23,;2,-2.69,;3.33,-1.93,;4.67,-2.69,;6,-1.93,;6,-.38,;7.34,.38,;7.34,1.93,;6,2.69,;8.67,2.69,;10,1.93,;10,.38,;8.67,-.38,;8.67,-1.93,;11.34,2.69,;12.67,1.93,;14,2.69,;14,4.23,;12.67,5,;11.34,4.23,;.67,-1.93,;-.67,-2.69,)|
Structure:
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