Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500122
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
275±n/a nM
Citation
 Yao, ZLuo, CXie, YYue, LWan, WZhang, YJiang, HChen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500122
Synonyms:
US11021457, Compound 134
Type:
Small organic molecule
Emp. Form.:
C23H23N3O7
Mol. Mass.:
453.4446
SMILES:
CCOC(=O)C1CC(=O)C(=CNc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)C(=O)C1 |(-5.6,-7.88,;-4.26,-7.11,;-4.26,-5.57,;-2.93,-4.8,;-1.6,-5.57,;-2.93,-3.26,;-4.26,-2.49,;-4.26,-.95,;-5.6,-.18,;-2.93,-.18,;-2.93,1.36,;-4.26,2.13,;-4.26,3.67,;-5.6,4.44,;-5.6,5.98,;-4.26,6.75,;-2.93,5.98,;-1.47,6.46,;-.7,7.79,;-.56,5.21,;-1.47,3.97,;-2.93,4.44,;.98,5.21,;1.75,3.88,;3.29,3.88,;4.06,5.21,;5.6,5.21,;3.29,6.54,;1.75,6.54,;.98,7.88,;-1.6,-.95,;-.26,-.18,;-1.6,-2.49,)|
Structure:
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