Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500123
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
750±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500123
Synonyms:
US11021457, Compound 135
Type:
Small organic molecule
Emp. Form.:
C27H23ClN4O6
Mol. Mass.:
534.948
SMILES:
Clc1ccc(NC(=O)C2CC(=O)C(=CNc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)C(=O)C2)cc1 |(-8.01,-6.06,;-6.47,-6.06,;-5.7,-4.72,;-4.16,-4.72,;-3.39,-6.06,;-1.85,-6.06,;-.52,-5.29,;.82,-6.06,;-.52,-3.75,;-1.85,-2.98,;-1.85,-1.44,;-3.19,-.67,;-.52,-.67,;-.52,.87,;-1.85,1.64,;-1.85,3.18,;-3.19,3.95,;-3.19,5.49,;-1.85,6.26,;-.52,5.49,;.95,5.97,;1.72,7.3,;1.85,4.72,;.95,3.48,;-.52,3.95,;3.39,4.72,;4.16,3.39,;5.7,3.39,;6.47,4.72,;8.01,4.72,;5.7,6.06,;4.16,6.06,;3.39,7.39,;.82,-1.44,;2.15,-.67,;.82,-2.98,;-4.16,-7.39,;-5.7,-7.39,)|
Structure:
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