Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500132
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500132
Synonyms:
US11021457, Compound 144
Type:
Small organic molecule
Emp. Form.:
C27H21ClF3N3O5
Mol. Mass.:
559.921
SMILES:
FC(F)(F)c1ccc(Cl)c(c1)C1CC(=O)C(=CNc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)C(=O)C1 |(1.12,-8.01,;-.22,-7.24,;-.99,-8.57,;.55,-5.91,;-1.55,-6.47,;-2.93,-7.21,;-4.26,-6.44,;-4.26,-4.9,;-5.6,-4.13,;-2.93,-4.13,;-1.6,-4.9,;-2.93,-2.59,;-4.26,-1.82,;-4.26,-.28,;-5.6,.49,;-2.93,.49,;-2.93,2.03,;-4.26,2.8,;-4.26,4.34,;-5.6,5.11,;-5.6,6.65,;-4.26,7.42,;-2.93,6.65,;-1.47,7.12,;-.7,8.46,;-.56,5.88,;-1.47,4.63,;-2.93,5.11,;.98,5.88,;1.75,4.54,;3.29,4.54,;4.06,5.88,;5.6,5.88,;3.29,7.21,;1.75,7.21,;.98,8.55,;-1.6,-.28,;-.26,.49,;-1.6,-1.82,)|
Structure:
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