Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500133
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, ZLuo, CXie, YYue, LWan, WZhang, YJiang, HChen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500133
Synonyms:
US11021457, Compound 145
Type:
Small organic molecule
Emp. Form.:
C26H21ClFN3O5
Mol. Mass.:
509.913
SMILES:
Fc1cc(Cl)ccc1C1CC(=O)C(=CNc2cccc3C(=O)N(Cc23)C2CCC(=O)NC2=O)C(=O)C1 |(-.26,-4.03,;-1.6,-4.8,;-1.6,-6.34,;-2.93,-7.11,;-2.93,-8.65,;-4.26,-6.34,;-4.26,-4.8,;-2.93,-4.03,;-2.93,-2.49,;-4.26,-1.72,;-4.26,-.18,;-5.6,.59,;-2.93,.59,;-2.93,2.13,;-4.26,2.9,;-4.26,4.44,;-5.6,5.21,;-5.6,6.75,;-4.26,7.52,;-2.93,6.75,;-1.47,7.23,;-.7,8.56,;-.56,5.98,;-1.47,4.74,;-2.93,5.21,;.98,5.98,;1.75,4.65,;3.29,4.65,;4.06,5.98,;5.6,5.98,;3.29,7.31,;1.75,7.31,;.98,8.65,;-1.6,-.18,;-.26,.59,;-1.6,-1.72,)|
Structure:
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