Reaction Details Report a problem with these data
Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500143
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500143
Synonyms:
US11021457, Compound 155
Type:
Small organic molecule
Emp. Form.:
C30H30N4O6
Mol. Mass.:
542.5824
SMILES:
O=C1N(Cc2c1cccc2NC=C1C(=O)CC(CC1=O)c1ccccc1N1CCOCC1)C1CCC(=O)NC1=O |(-.7,7.79,;-1.47,6.46,;-.56,5.21,;-1.47,3.97,;-2.93,4.44,;-2.93,5.98,;-4.26,6.75,;-5.6,5.98,;-5.6,4.44,;-4.26,3.67,;-4.26,2.13,;-2.93,1.36,;-2.93,-.18,;-4.26,-.95,;-5.6,-.18,;-4.26,-2.49,;-2.93,-3.26,;-1.6,-2.49,;-1.6,-.95,;-.26,-.18,;-2.93,-4.8,;-4.26,-5.57,;-4.26,-7.11,;-2.93,-7.88,;-1.6,-7.11,;-1.6,-5.57,;-.26,-4.8,;1.07,-5.57,;2.4,-4.8,;2.4,-3.26,;1.07,-2.49,;-.26,-3.26,;.98,5.21,;1.75,3.88,;3.29,3.88,;4.06,5.21,;5.6,5.21,;3.29,6.54,;1.75,6.54,;.98,7.88,)|
Structure:
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